Reaction: CDK2:CCNA phosphorylates TERF2
- in pathway: Telomere Extension By Telomerase
Outside of the S phase of the cell cycle, the shelterin complex subunit TERF2 (TRF2) is phosphorylated on serine residue S365. This phosphorylation is performed by the complex of CDK2 and cyclin A (CCNA). Phosphorylation of TERF2 at S365 prevents association of RTEL1 with telomeres, thus protecting t-loops from promiscuous unwinding and inappropriate activation of ATM (Sarek et al. 2019).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9686521
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9686521