Reaction: PP6-PPP6R3 dephosphorylates TERF2
- in pathway: Telomere Extension By Telomerase
The regulatory subunit PPP6R3 of the protein phosphatase complex PP6 facilitates PP6-mediated dephosphorylation of the shelterin subunit TERF2 at serine residue S365. PP6-mediated dephosphorylation of TERF2 occurs at the S phase entry and enables timely loading of RTEL1 to telomere ends (Sarek et al. 2019).
Reaction - small molecule participants:
Pi [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-9686524
======
Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-9686524