Meta-Biol

• Pathways

The following GTPase activating proteins (GAPs) were shown to bind RHOF and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOF:GTP complex into the inactive RHOF:GDP complex (the study by Bagci et al. 2020 reported binding of GAPs to active RHOF without testing for RHOF-directed GAP activity and is cited as a supporting evidence):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)

The following candidate RHOF GAPs were reported by Bagci et al. 2020 to bind active RHOF, but their RHOF-directed GAP activity has not been tested:
ARHGAP5 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP21 (Bagci et al. 2020)
ARHGAP32 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
SYDE1 (Bagci et al. 2020)

The following GAPs were reported to not act on RHOF or were reported by Bagci et al. 2020 to not bind active RHOF without testing of their RHOF-directed GAP activity:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP35 (Amin et al. 2016); Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; Bagci et al. 2020)
OPHN1 (Amin et al. 2016; Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)