Reaction: HTR1A binds 5HT
- in pathway: Serotonin receptors
5-hydroxytryptamine receptors 1A (HTR1A), once bound to their physiological ligand serotonin (5HT), act on the CNS where they induce neuronal and presynaptic inhibition and behavioural effects (Stam et al. 1992). HTR1A mediates its actions by coupling with the G protein alpha-i/o subtype (Lin et al. 2002, Francken et al. 1998), inhibiting adenylate cyclase activity and thereby decreasing cellular cAMP levels.
Reaction - small molecule participants:
5HT [extracellular region]
Reactome.org reaction link: R-HSA-9693347
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Reaction input - small molecules:
serotonin(1+)
Reaction output - small molecules:
Reactome.org link: R-HSA-9693347