Reaction: nsp3-4 cleaves itself
- in pathway: Maturation of replicase proteins
This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004).
To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9694601
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9694601