Reaction: nsp3 cleaves nsp1-4
- in pathway: Maturation of replicase proteins
Glycosylated nsp3 (papain-like protease) of SARS-CoV-2 cleaves the N-proximal polyprotein regions at three sites. Polyprotein cleavage is essential for generation of the nsp1-4 viral proteins, and therefore essential for virus replication (Swaim et al, 2020).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9694625
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9694625