Reaction: 3CLp cleaves pp1ab
- in pathway: Maturation of replicase proteins
Main protease of SARS-CoV-2 (3CLpro, nsp5) cleaves all cleavage sites of pp1a and ppa1b starting with nsp4/5, thus cleaving itself, and all the cytosolic RTC proteins. This is essential for maturation of the viral replicase complex and for making it fully functional (Du et al, 2021).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9694732
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9694732