Reaction: Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)
- in pathway: Transcription of SARS-CoV-2 sgRNAs
SARS-CoV-2 transcripts are polyadenylated (Ravindra et al. 2020, Kim et al. 2020), similar to their SARS-CoV-1 counterparts. SARS-CoV-2 subgenomic RNAs (sgRNAs) carry poly(A) tails of the meadian lenght of 47 nucleotides. The poly(A) tails of sgRNAs of SARS-CoV-2 are shorter than the poly(A) tails of the full-length SARS-CoV-2 genomic RNA (Kim et al. 2020).
SARS-CoV-1 plus strand sgRNAs share a 3'UTR with the plus strand genomic RNA, and as this 3'UTR possesses a polyadenylation signal, they undergo polyadenylation by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).
SARS-CoV-1 plus strand sgRNAs share a 3'UTR with the plus strand genomic RNA, and as this 3'UTR possesses a polyadenylation signal, they undergo polyadenylation by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).
Reaction - small molecule participants:
PPi [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9694733
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-9694733