Reaction: Spike protein gets N-glycosylated
- in pathway: Maturation of spike protein
Glycosyltransferases in the endoplasmatic reticulum are responsible for the attachment of numerous high-mannose N-glycans on the SARS-CoV-2 spike protein. After virion assembly and release these glycosidations are required for fusion with host cells (Watanabe et al, 2020, Breuer et al, 2001).
O-glycosylations do occur on the Spike protein with an average overall frequency per site of less than 50 percent (Sanda et al, 2020).
O-glycosylations do occur on the Spike protein with an average overall frequency per site of less than 50 percent (Sanda et al, 2020).
Reaction - small molecule participants:
DOLP [integral component of lumenal side of endoplasmic reticulum membrane]
(Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-9694793
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Reaction input - small molecules:
glycan G00008
Reaction output - small molecules:
dolichyl phosphate(2-)
Reactome.org link: R-HSA-9694793