Reaction: Constitutive phosphorylation of FLT3 mutants
- in pathway: Signaling by FLT3 ITD and TKD mutants
Activating mutations in the juxtamembrane, kinase and extracellular regions of FLT3 lead to ligand-independent dimerization, trans-autophosphorylation and constitutive downstream signaling (Kiyoi et al, 1998; Yamamoto et al, 2001; Clark et al, 2004; Zheng et al, 2004; Stirewalt et al, 2004; Jiang et al, 2004; Schittenhelm et al, 2006; Reindl et al, 2006; Frohling et al, 2007; Breteinbeucher et al, 2009; Huang et al, 2016; reviewed in Klug et al, 2018; Staudt et al, 2018; Daver et al, 2019).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9695834
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9695834