Reaction: Defective rpoB in Mtb RNAP transcribes RNA polyanion
- in pathway: Antimicrobial action and antimicrobial resistance in Mtb
Mutations in several regions of bacterial RNA polymerase (RNAP) subunit rpoB disable binding of rifampicin, and recover enzymatic activity (Jin & Gross 1988, Telenti et al. 1993). The most clinically prevalent mutation associated with rifamycin resistance is S456L which accounts for 40-75% of all rifamycin resistant mutants (Stefan et al. 2018).
Reaction - small molecule participants:
PPi [cytosol]
RNTP [cytosol]
RNA polyanion [cytosol]
Reactome.org reaction link: R-HSA-9697084
======
Reaction input - small molecules:
ribonucleoside 5'-triphosphate
RNA polyanion
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-9697084