Reaction: AKT phosphorylates FOXO3 downstream of FLT3
- in pathway: FLT3 Signaling
AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of FLT3 and FLT3-ITD-mediated signaling (Scheijen et al, 2004; Brandts et al 2005; reviewed in Kazi and Roonstrand, 2019). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008; Yadav et al, 2018).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9699579
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9699579