Reaction: Autophosphorylation of ALK fusions
- in pathway: Signaling by ALK fusions and activated point mutants
After partner protein-mediated dimerization, ALK fusions are trans-autophosphorylated by the ALK kinase domain, leading to constitutive activation and downstream signaling (reviewed in Roskoski, 2013; Hallberg and Palmer, 2016; Della Corte et al, 2018).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9700181
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9700181