Reaction: Autophosphorylation of point mutants of ALK
- in pathway: Signaling by ALK fusions and activated point mutants
Oncogenic point mutations in ALK promote ligand-independent transautophosphorylation, leading to constitutive downstream signaling though pathways such as the MAP kinase, PI3K-AKT, PLC gamma and STAT3 cascades (Chen et al, 2008; Mosse et al, 2008; George et al, 2008; Wang et al, 2011; Ceccon et al, 2013; Ceccon et al, 2015; reviewed in Hallberg and Palmer, 2013; Della Corte et al, 2018).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9700186
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9700186