Reaction: ALK mutants phosphorylate SHC1
- in pathway: Signaling by ALK fusions and activated point mutants
SHC is tyrosine phosphorylated downstream of ALK fusion proteins. SHC may stimulate signaling through the MAP kinase cascade by virtue of its interaction with GRB2. The relative importance of this pathway to the oncogenic properties varies somewhat among different fusion proteins (Fujimoto et al, 1996; Trinei et al, 2000; Hernandez et al, 2002; Ren et al, 2012; reviewed in Hallberg and Palmer, 2013; Hallberg and Palmer, 2016).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9700193
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9700193