Reaction: Active ALK phosphorylates SRC
- in pathway: Signaling by ALK
SRC is phosphorylated on tyrosine 419 and tyrosine 216 downstream of activated ALK (Cussac et al, 2004). SRC signaling contributes to cellular proliferation, potentially through GRB2-SOS1 mediated RAS activation, although this has not been explicitly demonstrated (Cussac et al, 2004; reviewed in Chiarle et al, 2008; Palmer et al, 2009).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9700647
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9700647