Reaction: Active ALK phosphorylates JAK3
- in pathway: Signaling by ALK
JAK3 is phosphorylated downstream of active ALK signaling (Zamo et al, 2002; Amin et al, 2003; Lai et al, 2005; Han et al, 2006a, b) Signaling through JAK3 and STAT3 contributes to cellular survival downstream of ALK signaling (Lai et al, 2005; Shi et al, 2006; reviewed in Palmer et al, 2009).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9701488
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9701488