Reaction: HDACs deacetylate p-STAT3 dimers
- in pathway: STAT3 nuclear events downstream of ALK signaling
HDAC1, 2, and 3 deacetylate lysine 685 of STAT3. Deacetylation reduces the transcriptional activity of STAT3 dimers as assessed by reporter gene assays in HEK293 cells (Yuan et al, 2005).
Reaction - small molecule participants:
CH3COO- [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-9701565
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Reaction input - small molecules:
water
Reaction output - small molecules:
acetic acid
Reactome.org link: R-HSA-9701565