Reaction: PDE3B hydrolyses cAMP to AMP
- in pathway: G alpha (s) signalling events
Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3B inhibition promotes cardiac muscle contraction, a strategy used in heart failure.
Reaction - small molecule participants:
AMP [cytosol]
H2O [cytosol]
cAMP [cytosol]
Reactome.org reaction link: R-HSA-9705507
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Reaction input - small molecules:
water
3',5'-cyclic AMP(1-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-9705507