Reaction: H2O2 oxidises ferrohemoglobin to MetHb
- in pathway: Heme signaling
Extracellular ferrous (Fe2+) hemoglobin (FeHM) is readily oxidized into methemoglobin (MetHb) in the presence of reactive oxygen species (ROS) like hydrogen peroxide (H2O2) (Gouveia et al, 2017; Sadrzadeh et al, 1984).
Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).
Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).
Reaction - small molecule participants:
hydroxyl [extracellular region]
hydroxide [extracellular region]
H2O2 [extracellular region]
hydroxyl [extracellular region]
hydroxide [extracellular region]
H2O2 [extracellular region]
Reactome.org reaction link: R-HSA-9707504
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Reaction input - small molecules:
hydrogen peroxide
hydrogen peroxide
Reaction output - small molecules:
hydroxyl
hydroxide
hydroxyl
hydroxide
Reactome.org link: R-HSA-9707504