Reaction: FeHM dissociates from MetHb
- in pathway: Heme signaling
Methemoglobin (MetHb) is highly unstable, releasing free ferriheme (FeHM). The hydrophobic ferriheme, if not scavenged by serum proteins, rapidly intercalates into the plasma membrane of surrounding cells, catalyzing lipid oxidation (Balla et al, 1993).
Reaction - small molecule participants:
FeHM [extracellular region]
Reactome.org reaction link: R-HSA-9707516
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Reaction input - small molecules:
Reaction output - small molecules:
ferriheme b
Reactome.org link: R-HSA-9707516