Reaction: FeHM oxidises LDL,HDL
- in pathway: Heme signaling
Free heme initially binds to the lipoproteins LDL and HDL which are highly susceptible to oxidation by ferriheme (FeHM). The half-life of the heme:lipoprotein complex is longer than 20 sec. Heme is then transferred to the antioxidants albumin and hemopexin (Miller and Shaklai, 1999; Jeney et al, 2002)
Reaction - small molecule participants:
heme [extracellular region]
FeHM [extracellular region]
Reactome.org reaction link: R-HSA-9707586
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Reaction input - small molecules:
ferriheme b
Reaction output - small molecules:
ferroheme b
Reactome.org link: R-HSA-9707586