Reaction: CO binds to free ferrohemoglobin
- in pathway: Cytoprotection by HMOX1
Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).
Reaction - small molecule participants:
CO [extracellular region]
Reactome.org reaction link: R-HSA-9709317
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Reaction input - small molecules:
carbon monoxide
Reaction output - small molecules:
Reactome.org link: R-HSA-9709317