Reaction: CO binds to Cytochrome c oxidase
- in pathway: Cytoprotection by HMOX1
Carbon monoxide (CO) toxicity is the result of a combination of tissue hypoxia and direct CO-mediated damage at a cellular level, since not all the signs and symptoms presented can be explained only by the formation of carboxyhaemoglobin. CO binds to cytochrome c oxidase, the terminal enzyme in the electron transfer chain, reducing its activity. Regulation of reactive oxygen species (ROS) generation is possibly one of the key components in CO signaling and its interaction with mitochondria but also other heme proteins that generate ROS, such as NADPH oxidase (Alonso et al, 2003; Zuckerbraun et al, 2007; Ishigami et al, 2017; Motterlini and Foresti, 2017).
Reaction - small molecule participants:
CO [mitochondrial inner membrane]
Reactome.org reaction link: R-HSA-9709406
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Reaction input - small molecules:
carbon monoxide
Reaction output - small molecules:
Reactome.org link: R-HSA-9709406