Reaction: BIL scavenges O2.-
- in pathway: Cytoprotection by HMOX1
Bilirubin (BIL) is a physiologic antioxidant. It has a unique redox activity towards superoxide radicals (O2•−) which it readily scavenges. Bilirubin’s redox activity is particularly important in the brain, where it prevents excitotoxicity and neuronal death by scavenging O2•− during NMDA neurotransmission (Vasavda et al, 2019).
Reaction - small molecule participants:
O2.- [cytosol]
BIL [cytosol]
Reactome.org reaction link: R-HSA-9709879
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Reaction input - small molecules:
superoxide
bilirubin(2-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9709879