Reaction: BIL:ALB scavenges O2.-
- in pathway: Cytoprotection by HMOX1
Like unbound bilirubin (BIL) the bilirubin-albumin complex (BlL:ALB) scavenges superoxide. Small amounts of plasma bilirubin are sufficient to prevent oxidation of albumin-bound fatty acids as well as of the protein itself. This indicates a role for BIL:ALB as a physiological antioxidant in plasma and the extravascular space. There is however no evidence for a fully circular mechanism where all bilirubin is oxidized back to biliverdin to be available again as antioxidant (Stocker et al, 1987; Maghzal et al, 2009).
Reaction - small molecule participants:
BV [extracellular region]
O2.- [extracellular region]
Reactome.org reaction link: R-HSA-9709883
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Reaction input - small molecules:
superoxide
Reaction output - small molecules:
biliverdin(2-)
Reactome.org link: R-HSA-9709883