Reaction: BIL scavenges NO
- in pathway: Cytoprotection by HMOX1
Bilirubin (BIL) can serve as an endogenous scavenger of both nitric oxide (NO) and reactive nitrogen species, thus widening the protective role of bilirubin to other reactive species originating within the cellular environment. This ability is quite important in explaining some of the pathophysiological mechanisms involved in the cytoprotective function of the bile pigment against NO-related pathologies such as atherosclerosis, liver disease and neurodegenerative disorders (Mancuso et al, 2006; Kaur et al, 2003; Mancuso et al, 2003).
Reaction - small molecule participants:
NO [cytosol]
BIL [cytosol]
Reactome.org reaction link: R-HSA-9709885
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Reaction input - small molecules:
nitric oxide
bilirubin(2-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9709885