Reaction: ALK fusions phosphorylate IRS1
- in pathway: Signaling by ALK fusions and activated point mutants
IRS1 is phosphorylated downstream of NPM-ALK fusions (Fujimoto et al, 1996). ALK-dependent IRS phosphorylation activates the MAP kinase signaling pathway and promotes cellular proliferation, but direct binding of a RAS GEF such as GRB2:SOS1 has not been shown (reviewed in Chiarle et al, 2008; Roskoski, 2013).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9712082
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9712082