Reaction: ALK fusions phosphorylate PLCG1
- in pathway: Signaling by ALK fusions and activated point mutants
PLC gamma is phosphorylated downstream of ALK fusions, activating it. PLC gamma signaling promotes cellular proliferation and differentiation (Bai et al, 1998; reviewed in Chiarle et al, 2008; Palmer et al, 2009).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9712086
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9712086