Reaction: ALK fusions phosphorylate FRS
- in pathway: Signaling by ALK fusions and activated point mutants
FRS proteins are phosphorylated downstream of ALK fusions in a manner that depends on ALK kinase activity (Chikamori et al, 2007). FRS binding and activation contributes to the transformation activity of NPM-ALK, possibly by stimulating MAP kinase or PI3K signaling, consistent with established roles in other pathways (reviewed in Palmer et al, 2009; Gotoh, 2008; Sato and Gotoh, 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9712087
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9712087