Reaction: ANO2 dimer binds Ca2+
- in pathway: Olfactory Signaling Pathway
Each monomer of the ANO2 dimer (TMEM16B dimer) can bind up to 2 calcium ions at locations in transmembrane helix 6-8 (inferred from mouse Ano1, Tmem16a). The first intracellular loop also plays a role in the calcium sensitivity of ANO2 but the mechanism is unknown as this site does not appear to strongly bind calcium (inferred from mouse Ano1, Tmem16a).
Reaction - small molecule participants:
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-9712195
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-9712195