Reaction: ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region
- in pathway: Olfactory Signaling Pathway
Each monomer of the ANO2 dimer contains a pore that translocates chloride ions according to the concentration gradient from the cytosol to the extracellular region (Stöhr et al. 2009, and inferred from mouse homologs). Binding of calcium ions to sites in a transmembrane helix of each monomer increases the permeability of the pore to chloride ions.
Reaction - small molecule participants:
Cl- [extracellular region]
Cl- [cytosol]
Reactome.org reaction link: R-HSA-9712204
======
Reaction input - small molecules:
chloride
Reaction output - small molecules:
chloride
Reactome.org link: R-HSA-9712204