Reaction: ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol
Upon binding IP3, ITPR3 transports calcium ions across the endoplasmic reticulum membrane according to the concentration gradient from the ER lumen to the cytosol (Lock et al. 2018). The mouse homolog of ITPR3 is expressed in type II (umami, sweet, bitter) taste cells where it responds to IP3 produced by PLCB2 (Hisatsune et al. 2007).
Reaction - small molecule participants:
Ca2+ [cytosol]
Ca2+ [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9717215
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-9717215