Reaction: CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region
- in pathway: Sensory perception of salty taste
The CALHM1 channel transports ATP across the plasma membrane in response to depolarization of the membrane (Taruno et al. 2013). Heteromeric complexes containing both CALHM1 and CALHM3 have voltage-gating that is faster than homomeric CALHM1 complexes and resembles the voltage gating observed in taste cells in vivo (Ma et al. 2018). In mice, knockout of Calhm1 strongly affected voltage-gated currents associated with ATP release and Calhm1 and Calhm3 are sorted to the basolateral membrane of taste cells.
Reaction - small molecule participants:
ATP [extracellular region]
ATP [cytosol]
ATP [extracellular region]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9717392
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ATP(4-)
ATP(4-)
Reactome.org link: R-HSA-9717392