Reaction: SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol
SCN2A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Ahmed et al. 1992, Ben-Shalom et al. 2017). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Differences in SCN2A alleles appear to be related to autism spectrum disorder (Ben-Shalom et al. 2017).
Reaction - small molecule participants:
Na+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-9717396
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Reaction input - small molecules:
sodium(1+)
Reaction output - small molecules:
sodium(1+)
Reactome.org link: R-HSA-9717396