Reaction: Nucleoprotein is ADP-ribosylated
- in pathway: Maturation of nucleoprotein
This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
Nucleoprotein (N) is ADP-ribosylated. The modification is maintained both in the cell and in virions (Grunewald et al, 2018). Members of the protein mono-ADP-ribosyltransferase (PARP) enzyme family are thought to catalyze this reaction (Fehr et al. 2020)
Nucleoprotein (N) is ADP-ribosylated. The modification is maintained both in the cell and in virions (Grunewald et al, 2018). Members of the protein mono-ADP-ribosyltransferase (PARP) enzyme family are thought to catalyze this reaction (Fehr et al. 2020)
Reaction - small molecule participants:
NAM [cytosol]
H+ [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-9729279
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
hydron
Reactome.org link: R-HSA-9729279