Reaction: SRPK1/2 phosphorylates nucleoprotein
- in pathway: Maturation of nucleoprotein
Full phosphorylation of SARS-CoV-2 nucleoprotein (N) depends on priming phosphorylations on at least two sites by SRPK1/2 protein kinases (Heaton et al, 2020; Carlson et al, 2020). Both kinases are monomers that need a magnesium cofactor to work, and are activated through phosphorylation by CK2 kinase (Daub et al, 2002).
Reaction - small molecule participants:
H+ [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9729330
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
hydron
ADP(3-)
Reactome.org link: R-HSA-9729330