Reaction: SARS-CoV-2 nsp3 deISGylates ISGylated IRF3
The endopeptidase activity of SARS-CoV-2 nsp3 (PLpro) includes cleavage of ISG15 from ISGylated proteins, so called deISGylation (Leite et al, 2021). Since interferon responsive factor 3 (IRF3) is ISGylated this activity contributes to the cleavage of IRF3 and attenuates type I interferon responses (Freitas et al, 2020; Shin et al, 2020).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9729725
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9729725