Reaction: SARS-CoV-2 nsp3 cleaves IRF3
SARS-CoV-2 nsp3 protease (PLpro) specifically cleaves IRF3 at the LGGG motif and decreases IRF3 levels in COVID-19. Infection with a mutant having inhibited protease activity did not decrease IRF3 levels, demonstrating that the decrease of IRF3 is linked to the protease activity of nsp3 (Moustaqil et al, 2021). The nsp3-mediated cleavage of IRF3 attenuates type I interferon responses.
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-9729730
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-9729730