Reaction: JAK1-mediated phosphorylation of RAF1
- in pathway: IFNG signaling activates MAPKs
In response to IFNG (interferon-gamma) treatment, JAK1 mediates phosphorylation of RAF1 on an unknown tyrosine residue. As there is direct binding between JAK1 and RAF1, and as JAK1 tyrosine kinase activity is necessary, it is plausible that JAK1 is the tyrosine kinase that acts on RAF1, but indirect JAK1-mediated phosphorylation of RAF1 has not been excluded (Sakatsume et al. 1998).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9732738
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9732738