Reaction: JAK1-activated RAF1 phosphorylates MAPKs
- in pathway: IFNG signaling activates MAPKs
RAF1, activated downstream of IFNG (interferon-gamma) in a JAK1-dependent and RAS-independent manner, phosphorylates ERKs: MAPK1 (ERK2) and MAPK3 (ERK1) (Sakatsume et al. 1998). IFNG-mediated activation of ERKs may contribute to transient attenuation of TGF-beta signaling through ERK-mediated phosphorylation of SMAD2 and SMAD3, but a long-term effect depends on IFNG-mediated transcription of SMAD7, an inhibitor of TGF-beta signaling (Ulloa et al. 1999).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9732753
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9732753