Reaction: L-Glutamate binds GRM1 (mGluR1)
In taste bud cells, L-glutamate binds a truncated isoform of GRM1 (mGluR1) that has about 100x lower affinity for L-glutamate than the full-length, brain-expressed isoform does (inferred from rat homologs). Binding of L-glutamate to GRM1 activates an incompletely characterized signaling cascade that results in depolarization of the taste bud cell.
Reaction - small molecule participants:
L-Glu [extracellular region]
Reactome.org reaction link: R-HSA-9737035
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Reaction input - small molecules:
L-glutamate(1-)
Reaction output - small molecules:
Reactome.org link: R-HSA-9737035