Reaction: GMPS dimer transforms 6TXMP to 6TGMP
- in pathway: Azathioprine ADME
GMP synthase (glutamine-hydrolyzing) (GMPS) is involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP for cellular processes. GMPS forms a dimer and can act on many drugs that are nucleobase- and nucleoside-based compounds (Welin et al. 2013). Here, 6-thioxanthosine 5'-monophosphate (6TXMP) is transformed to 6-thioguanosine monophosphate (6TGMP), the first 6-thioguanine nucleotide (6-TGN).
Reaction - small molecule participants:
PPi [cytosol]
6TGMP [cytosol]
L-Glu [cytosol]
H+ [cytosol]
AMP [cytosol]
H2O [cytosol]
6TXMP [cytosol]
ATP [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-9748957
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Reaction input - small molecules:
water
6-Thioxanthine 5'-monophosphate(2-)
ATP(4-)
L-glutamine zwitterion
Reaction output - small molecules:
diphosphate(3-)
6-Thioguanosine monophosphate(2-)
L-glutamate(1-)
hydron
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-9748957