Reaction: GUK1 phosphorylates 6TdGMP to 6TdGDP
- in pathway: Azathioprine ADME
6-thioguanine nucleotides (6-TGNs) consist of 6-thio(deoxy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.
Guanylate kinase (GUK1) is an essential nucleoside monophosphate kinase that catalyzes the phosphorylation of deoxyguanosine-monophosphate (dGMP) to yield dGDP, an important precursor for nucleotide synthesis (Agarwal et al. 1978). As well as this physiological role, GUK1 converts therapeutic prodrugs into their pharmacologically active metabolites. In this example, GUK1 phosphorylates 6-thiodeoxyguanosine monophosphate (6TdGMP) to 6-thiodeoxyguanosine diphosphate (6TdGDP) (Miller et al. 1977, review in Karran 2006).
Guanylate kinase (GUK1) is an essential nucleoside monophosphate kinase that catalyzes the phosphorylation of deoxyguanosine-monophosphate (dGMP) to yield dGDP, an important precursor for nucleotide synthesis (Agarwal et al. 1978). As well as this physiological role, GUK1 converts therapeutic prodrugs into their pharmacologically active metabolites. In this example, GUK1 phosphorylates 6-thiodeoxyguanosine monophosphate (6TdGMP) to 6-thiodeoxyguanosine diphosphate (6TdGDP) (Miller et al. 1977, review in Karran 2006).
Reaction - small molecule participants:
6TdGDP [cytosol]
ADP [cytosol]
ATP [cytosol]
6TdGMP [cytosol]
Reactome.org reaction link: R-HSA-9748963
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Reaction input - small molecules:
ATP(4-)
6 thiodeoxyguanosine monophosphate (2-)
Reaction output - small molecules:
6 thiodeoxyguanosine diphosphate (3-)
ADP(3-)
Reactome.org link: R-HSA-9748963