Reaction: NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP
- in pathway: Azathioprine ADME
6-thioguanine nucleotides (6-TGNs) consist of 6-thio(dexoy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.
Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thiodeoxyguanosine diphosphate (6TdGDP) to 6-thiodeoxyguanosine triphosphate (6TdGTP) (Karner et al. 2010).
Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thiodeoxyguanosine diphosphate (6TdGDP) to 6-thiodeoxyguanosine triphosphate (6TdGTP) (Karner et al. 2010).
Reaction - small molecule participants:
6TdGTP [cytosol]
ADP [cytosol]
6TdGDP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9748969
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Reaction input - small molecules:
6 thiodeoxyguanosine diphosphate (3-)
ATP(4-)
Reaction output - small molecules:
6-thiodeoxyguanosine triphosphate (4-)
ADP(3-)
Reactome.org link: R-HSA-9748969