Reaction: NME1:2 hexamer phosphorylates 6TGDP to 6TGTP
- in pathway: Azathioprine ADME
6-thioguanine nucleotides (6-TGNs) consist of 6-thio(deoxy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.
Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thioguanosine diphosphate (6TGDP) to 6-thioguanosine triphosphate (6TGTP) (Karner et al. 2010).
Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thioguanosine diphosphate (6TGDP) to 6-thioguanosine triphosphate (6TGTP) (Karner et al. 2010).
Reaction - small molecule participants:
ADP [cytosol]
6TGTP [cytosol]
ATP [cytosol]
6TGDP [cytosol]
Reactome.org reaction link: R-HSA-9748999
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Reaction input - small molecules:
ATP(4-)
6-Thioguanosine diphosphate(3-)
Reaction output - small molecules:
ADP(3-)
6 thioguanosine triphosphate(4-)
Reactome.org link: R-HSA-9748999