Reaction: UGT1A6 glucuronates ST
- in pathway: Aspirin ADME
A side effect of phenolic glucuronidation of salicylate (ST) (resulting in the O-glucuronide) is acyl glucuronation. In particular UGT1A6 glucuronates ST preferentially at the carboxyl group (Hutt et al, 1986; Iyanagi, 2007; Kuehl et al, 2006).
Reaction - small molecule participants:
SAAG [endoplasmic reticulum lumen]
UDP [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9749977
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Reaction input - small molecules:
salicylate
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
salicylic acyl beta-D-glucuronide (1-)
UDP
Reactome.org link: R-HSA-9749977