Reaction: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA
- in pathway: Aspirin ADME
2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015)
Reaction - small molecule participants:
2,3-DHBA [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9749986
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Reaction input - small molecules:
dioxygen
salicylate
Reaction output - small molecules:
2,3-dihydroxybenzoate
water
Reactome.org link: R-HSA-9749986