Reaction: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid
- in pathway: Aspirin ADME
GLYAT-like enzymes catalyze the transfer of acyl groups from acyl-CoA onto glycine (Webster et al, 1976). Conjugation of 2,5-DHBA with glycine yields gentisuric acid which is detected after aspirin intake (Wilson et al., 1978).
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
gentisuric acid [mitochondrial matrix]
Gly [mitochondrial matrix]
2,5-DHB-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-9750001
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Reaction input - small molecules:
glycine zwitterion
2,5-dihydroxybenzoyl-CoA
Reaction output - small molecules:
coenzyme A(4-)
Gentisuric acid
Reactome.org link: R-HSA-9750001