Reaction: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA
- in pathway: Aspirin ADME
2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
2,5-DHBA [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
ST (hepatocyte) [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-9750016
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Reaction input - small molecules:
dioxygen
salicylate
Reaction output - small molecules:
water
2,5-dihydroxybenzoate
Reactome.org link: R-HSA-9750016